PMVK anticorps (Middle Region)

N° du produit ABIN3032231

L’anticorps Lapin Polyclonal anti-PMVK a été validé pour WB et IHC (p). Il convient pour détecter PMVK dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour PMVK anticorps (Middle Region) (ABIN3032231)

Antigène: PMVK (Phosphomevalonate Kinase (PMVK))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PMVK est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-PMVK anticorps

Épitope: Middle Region

Purification: Antigen affinity

Immunogène: An amino acid sequence from the middle region of human PMVK (EQSRQQRGWVFTPGVDD) was used as the immunogen for this PMVK antibody (100% homologous in human and mouse).

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the PMVK antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the PMVK antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur PMVK

Antigène: PMVK (Phosphomevalonate Kinase (PMVK))

Autre désignation: PMVK

Sujet: Phosphomevalonate kinase is a cytosolic enzyme that catalyzes the conversion of mevalonate-5-phosphate to mevalonate-5-diphosphate. It is mapped to chromosome 1p13-1q22-23 and spans more than 8.4 kb in the human genome. PMVK is a peroxisomal protein which requires the C-terminal peroxisomal targeting signal, Ser-Arg-Leu, for localization to the organelle. It was expressed highly in heart, liver, skeletal muscle, kidney and pancreas and slightly lower in brain, placenta, and lung. And PMKase gene expression is subject to regulation by sterol at the level of transcription. It is a single copy gene covering less than 15 kb in the human genome. The human PMKase amino acid sequence contains a consensus peroxisomal targeting sequence(PTS-1), Ser-Arg-Leu, at the C terminus of the protein.

UniProt: Q15126